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Description
Opportunities for progress include rational brain-exposure design with efflux avoidance, development of microglia-directed delivery systems, and incorporation of human target-engagement biomarkers into early-phase studies

The reconstitution solvent should be added slowly down the side of the vial rather than directly onto the lyophilised cake to minimise mechanical disruption

These powerhouses are in a constant physiological balance of dividing and fusing

Archives of Neurology

Commercial availability is anticipated in 2026 at the earliest

More than 70 tyrosine kinase inhibitors (TKI) have already been approved and successfully used in clinical practice for several tumors, such as metastatic breast cancer, metastatic renal-cell carcinoma, advanced hepatocellular carcinoma, chronic myeloid leukemia, and gastrointestinal stroma tumor [148]
