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Wound healing is divided into four phases, including hemostasis (blood clot formation), inflammation (infiltration of immune cells), proliferation (angiogenesis, granulation, epithelialization, and ECM remodeling through proliferation and migration of fibroblasts and keratinocytes), as well as skin layer maturation (wound contraction and inflammation resolution)

MaccioniLGaoBLeclercqSPirlotBHorsmansYDe TimaryPet al

As such, it is essential to employ screening strategies within appropriately defined experimental settings that can capture this complexity

doi: 10.1038/s41581-021-00482-8

Prenyldiphosphate synthase, subunit 1 (PDSS1) and OH-benzoate polyprenyltransferase (COQ2) mutations in ubiquinone deficiency and oxidative phosphorylation disorders