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This combination has been explored for its potential impact on metabolic processes and cellular studies

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Methionine restriction obtained through dietary limitation or metabolic mutations extends lifespan in different species including yeast 6,7,8 , worms 9,10 , and mammals 11,12

Deficiency in either B6 or B12 can lead to an increase in homocysteine levels, which also increases the risk of many negative health issues

With this in mind, in the last decade, many efforts have been made to use other treatments for cancer in combination with tuberculosis to increase the effectiveness of CAR-T cell therapy, especially in solid tumors

Proper linker-payload design maximizes therapeutic efficacy, reduces off-target toxicity, and maintains a consistent DAR for reliable ADC performance