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AD patients frequently have low vitamin E concentrations in their cerebrospinal fluid (due to accelerated consumption of vitamin E in the brain/cerebrospinal fluid caused by OS)

Free Radic Biol Med 69:403416 Leal S, Ricardo Jorge DO, Joana B, Maria SS, Isabel SS (2017) Heavy alcohol consumption effects on blood pressure and on kidney structure persist after long-term withdrawal

The predisposition of different variants enhancing the susceptibility of oxidizing denatured Hb (Heinz bodies) to metabolites other than bilirubin is an area that needs to be explored to gain new insights on the heterogeneity of this disease phenotype

[DOI] [PMC free article] [PubMed] [Google Scholar] 210.Miller M.R

Glutathione status can be assessed by measuring glutathione directly in blood or red blood cells and by monitoring levels of gamma-glutamyltransferase (GGT), the enzyme that regenerates extracellular reduced glutathione

Acknowledgements This work is supported by the National Natural Science Foundation of China under grants Nos