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In anterograde regulation, proteins encoded by the nuclear genome are transferred to the mitochondria to perform functions (71), while in retrograde regulation, the signal generated from mitochondria passes into the nucleus to induce gene expression, which occurs when mitochondrial homeostasis is interrupted by hypoxia or mutation in mtDNA, or mitochondrial Ca 2+ release (72, 73)

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A bidirectional arrow from this semiquinone points to ubiquinone (CoQ 10 ), the fully oxidized ubiquinone form that has two carbonyl groups on the head group

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Pero el consumo diario es de 8-15 gramos, dividido en 2 o 3 consumos a lo largo del da

A meta-nalysis showed that, compared with placebo/no intervention, the treatment with acetyl-l-carnitine significantly decreased the symptoms of depression, with fewer adverse events than those seen with established antidepressants [94]