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doi: 10.1097/01.ogx.0000279291.86611.46
Within one-carbon metabolism, serum folate is typically lowest during menses and rises into the luteal phase, while plasma homocysteine is lowest in the luteal phase and higher in the follicular/peri-ovulatory window, consistent with hormonally patterned shifts in methyl-group demand, oxidative stress, and inflammatory signaling across the cycle [143]
This facilitates the development and support of the cardiovascular system, the hepatic system, and the endocrine system
