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We first titrated an extensive range of concentrations of each dimeric macrocycle to determine the optimal concentration to induce proliferation in normal human epidermal keratinocytes (NHEK)

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Cycling the protocol, taking periodic breaks of two to four weeks before resuming, may help reset receptor sensitivity

The other structures maintain cell proximity but are not rate limiting as the width of the lateral space below the TJ is estimated to be 75 13 compared with 49 or 5060 for the TJ pores in villi or crypts, respectively

Among these, superparamagnetic iron oxide nanoparticles are particularly advantageous due to their favorable magnetic properties, excellent biocompatibility, and high specific surface area [269, 383]