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As previously discussed, A 1-42 is the primary constituent of senile plaques, one of the hallmarks of Alzheimer's disease pathology

doi: 10.3389/fpls.2018.01659 Received 08 June 2018 Accepted 25 October 2018 Published 15 November 2018 Volume 9 - 2018 Edited by Nikolaos E

71 ROS can also activate downstream effectors like PKC 72 and JNK, 73 which are independently associated with DPN pathology

Nature 641, 10171028

Identification of nicotinamide Nmethyltransferase as a promising therapeutic target against diabetic cardiomyopathy

[30] [31] The enzyme is present at high levels in the liver and the lining of the stomach