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Biochemistry 61 , 17431756 (2022)

In this report, we found that the induction of MT isoforms (MT1E, MT1F, and MT2A) was found only in HK-2 cells with GSH pre-depletion (Figure 3D)

First, the sulfonation reaction saturates and that allows more NAPQI to accumulate ([7, 24]) and second, the increased amount of NAPQI exhausts the liver stores of reduced glutathione (GSH)[6] as well as the livers capacity to synthesize new GSH

Mol Cell Biochem 286:95101, PMID: 16583144 Halliwell B, Gutteridge JMC (1989) Free radicals in biology and medicine

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