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As for PDPN targeting, the relief of the inhibitory signal delivered through the CD47-SIRP- binding on macrophages could generate a pro-inflammatory TME favoring the anti-MB immune response, as indicated for other tumor types (287, 288)

Laboratory Animal Res

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655 In addition to its role in glycolysis and ATP production, PKM2 also regulates the redirection of glycolytic intermediates to the pentose phosphate pathway, thereby generating NADPH, which is critical for cellular redox homeostasis, 656 thus shielding cancer cells from oxidative stress

The Assiut University Faculty of Medicines ethical committee gave its approval to the research protocol (IRB number 17300628)

Recent findings indicating that MSCs can transfer mitochondria to damaged tissue represent another intriguing mechanism that could be beneficial in PD therapy due to the proposed central role of damaged mitochondria in neurodegeneration of DA neurons 47