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TR-FRET ternary complex assay The TR-FRET assay was adapted from the following workflows previously reported 39,40

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Relevance to manganese toxicity

Sauter [284] investigated the effect of an aspalathin-enriched extract of unfermented rooibos (15% aspalathin) on the plasma antioxidant status of 20 subjects who were given an oral dose (250 mg/tablet) twice daily for 14 days with diet restrictions to ensure low flavonoid intake during the study period

Nevertheless, direct evidence in mammalian skin disease models remains necessary to confirm this therapeutic potential
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