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Gene Expression Modulation (Transcriptomic Remodeling) A landmark systems-biology analysis revealed that GHK-Cu can upregulate 31% of human genes associated with tissue repair while downregulating inflammatory and fibrotic pathways

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In doxorubicin (DOX)-induced cardiomyopathy models, SIRT1 downregulation exacerbates ferroptosis in cardiomyocytes, while its activation reduces oxidative stress and inhibits ferroptosis by increasing the expression of antioxidant enzymes such as GPX4

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