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The Liver-Skin Connection In the wellness world, we often say the skin is a reflection of what is happening inside the bodyparticularly in the liver

Disruption in ER function or sudden accumulation of misfolded proteins triggers ER stress responses ( Lysosomal oxidative stress: Lysosomes, involved in cellular waste degradation, contain enzymes and metal ions that can generate oxidative compounds such as hydrogen peroxide and hydroxyl radicals under oxidative stress conditions ( Nuclear oxidative stress: The nucleus, housing genetic material, is susceptible to oxidative damage

Proc Natl Acad Sci U S A (2014) 111(22):802530.10.1073/pnas.1401180111 87 WatersMJBrooksAJChhabraY

Aoyama K, Matsubara K, Kondo M, Murakawa Y, Suno M, Yamashita K, Yamaguchi S, Kobayashi S (2001) Nicotinamide- N -methyltransferase is higher in the lumbar cerebrospinal fluid of patients with Parkinsons disease

New Phytol 218:10891105

Less common symptoms include headaches, a thumping heart (palpitations), altered taste, loss of appetite, pale appearance, sore mouth or tongue and ringing in the ears (tinnitus)