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Individuals seeking to support fat metabolism and body composition under medical supervision may be candidates

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In many patients with severe primary IGF-I deficiency (SPIGFD) defined by low IGF-I (less than 3 SDS or the 2.5 th percentile), severe short stature (Height SDS less than 3), normal GH secretion and absence of acquired insensitivity to GH (discussed below) genetic defects may be absent

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Leptin acts on the hypothalamus (control center) in the brain, causing reduced food intake and burning of fat stores for energy (Meister 2000