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Although clinical and laboratory improvement can be seen with steroids, hepatic sarcoid can eventually progress to cause portal hypertension, bile duct depletion, and fibrotic changes, at which point steroids are unlikely to be of benefit

Conclusions and perspectives Over the past five decades, the discovery of rapamycin and the subsequent characterization of the TOR pathway have revolutionized our understanding of cellular growth, metabolism, and aging

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It has been particularly useful in cutaneous disease, hypercalcaemia, and some cases of neurosarcoidosis [11]

Reniere et al., 2015) (Table 2)