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LZD resulted in liver damage through elevating concentrations of transaminases such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST), alongside increasing alkaline phosphatase (ALP), lactate dehydrogenase (LDH), serum bilirubin, and lactate levels in rats (Vivekanandan et al., 2018)

Chang CH, Qiu J, OSullivan D, Buck MD, Noguchi T, Curtis JD, et al

Rgnier M, Van Hul M, Roumain M, Paquot A, de Wouters DA, Suriano F, Everard A, Delzenne NM, Muccioli GG, Cani PD

W.KimM.-J.ChaudharyM.et al (2024a)

Because of their hydrophilic nature, amino acids require a transporter system to cross the plasma membrane

Currently, human induced pluripotent stem cells (iPSC) and iPSC-derived neuronal cells, are routinely used by teams supported by the Foundation, to study CBS/H2S activity and its impact on cellular homeostasis