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In AD models, it decreases astrocyte activation through JAK2/STAT3 pathway inhibition, requiring careful dose control to preserve neuronal viability (275)

In this research, it was also demonstrated that JA treatments increase the phosphorylation levels of mitogen-activated protein kinase kinase (MEK1/2), suggesting that the MAP kinase signaling pathway is involved in the modulation of the antioxidant defense by JA (Shan et al., 2011)
The oncogenic potential of oxidative stress has been previously linked with PTC carcinogenesis [7]

Similarly, in a 28-day study, female animals showed elevated urine protein levels and the presence of crystals, although these effects were reversible during the recovery period (Nakano et al., 2014)
