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Sanz-Cuesta (2020) found that among 283 patients, 3 of 143 receiving injections developed a rash compared to 2 of 140 taking 1,000 g/day orally, a small difference consistent with the mechanistic picture

New England Journal of Medicine, 387(3)

If a day is missed, the research-sensible response is simply to resume the next scheduled dose, not to double up, because there is no acute deficit to make good and doubling only departs from the documented figure

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