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Infiltration is characterized by coolness and pallor to the skin as well as localized swelling or edema

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However, this marker is not completely clear because HMNT is only responsible for about 70% of histamine degradation the rest is done by the enzyme DAO

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[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Tran C.D., Katsikeros R., Manton N., Krebs N.F., Hambidge K.M., Butler R.N., Davidson G.P
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