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Once in the nucleus, Nrf2 binds to antioxidant response elements (AREs) in the promoter regions of target genes
doi: 10.1126/science.adg7942
FOXO6, as the most evolutionarily divergent member of this group, exhibits tissue-specific expression, particularly in liver, muscle, and neural tissues, and its effects on insulin signaling significantly differ from the other isoforms
Seccareccia E, Brodt P
The evidence base is now enormous
