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The antioxidant system involved in oxidative stress reduction is constituted by the glutathione-S transferase (GST)

Note there is controversial research on TB4 and cancer as increased TB4 levels are found in affected tissues of cancer patients compared to controls

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The primary antibodies were anti-CD68 (PG-M1, 1/100, Agilent Technologies-DAKO), anti-CD163 (10D6, 1/200, Leica), anti-FBP1 (EPR4619, 1/100, Abcam), anti-TREM2 (D814C, 1/100, Cell Signaling Technology), anti-CD1C (EPR23189-196, 1/1000, Abcam), anti-G6PD (EPR20668, 1/2000, Abcam), and anti-CHI3L1 (EPR19078-157, 1/250, Abcam)

This finding is consistent with the pathophysiology

TST in cardiovascular and kidney diseases The functions of TST in mitigating oxidative stress and maintaining redox homeostasis are increasingly recognized as central to the pathogenesis of atherosclerosis, which further contributes to ischemic stroke and chronic kidney disease (CKD) [126,127]