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We further identified the glutamine and alanine (the top two amino acids increased in serum from GCGR-KO mice) as inducers of cell VGF upregulation (Fig

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doi: 10.1101/gad.17420111 84 WuYJiaCLiuWZhanWChenYLuJet al

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P53 and p21 are then capable of contributing to the increase in intracellular ROS during senescence, providing a positive feedback loop for the maintenance of the senescence phenotype (Passos et al., 2010

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