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These initial studies demonstrated that fragments as small as tri- and tetrapeptides retained the desired procognitive/antidementia properties of Nle 1 -AngIV

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Among them is amylin, a hormone whose analogs were once seen as promising candidates to become weight-loss and antidiabetic medicines

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Similarly, the structure of the dipeptide Val-Tyr complex obtained by co-crystallisation of DAP BII (WT) with angiotensin IV (Val-Tyr-Ile-His-Pro-Phe) (dipeptide complex III, Table S1) is consistent with the above catalytic mechanism