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Nicotine may also contribute to the hardening of arterial walls, leading to heart attacks

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Reward Pathway Activation : Nicotines repeated activation of the brains reward pathway leads to neuroadaptations, where the brain becomes less responsive to natural rewards

Via the same physics that govern HEPA filtration, they are even more efficient at capturing both larger and smaller particles

10.1128/mSystems.00184-17 17 ByrneG

In trying to protect your mind from the neuro-chemical influence of the toxic natural pesticide nicotine, in some brain regions it actually desensitized important neuro-chemical circuits by reducing neurotransmitter receptor sites (down-regulation), in other regions by increasing the number of receptors (up-regulation), and still others by diminishing the number of transporters