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Interestingly, in experiments using hamsters the cuprizone concentration needed to be increased to 3% or even 5%compared to 0.2%0.5% in experiments on mice or ratto induce brain alterations

In severe cases of deficiency, our experienced healthcare providers may recommend an initial treatment plan that involves frequent injections, potentially daily or every other day, for one to two weeks

Puthia et al., 2020[110]

Despite these promising findings, current evidence remains largely preclinical

It is produced in the cytosol and then pumped into the mitochondria

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