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[0004] To achieve a durable response with ADCs, the field is trending towards arming antibodies with supertoxic drugs that kill both dividing and resting tumor cells {e.g., PBD and other DNA chelators) and are orders of magnitude more potent than microtubule inhibitors such as auristatin derivatives (Jeffrey et al
10.1073/pnas.96.13.7324
2016 Jul 13;36(28):7428-40
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C ch: Cc qu trnh xy dng t bo mi, sa cha cc m tn thng lun c s tham gia ca Glutathione, gip tng cng h thng min dch
Liu Y, Wu G, Tao X, Dong J, Shi T, Shi C
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