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Primary mutations of the mtDNA include point mutations affecting protein coding regions of the genome and mt-tRNA genes which alter mitochondrial protein synthesis

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TMAO and Acute Coronary Syndrome (ACS) More than half of cardiovascular deaths are caused by ACS, and the main cardiovascular disorder causing these acute cardiovascular events is the development of atherosclerosis ( In summary, TMAO is an independent risk factor for the risk estimation of malignant cardiovascular disease

The symptoms include anorexia, weight loss, muscle loss, skeletal muscle atrophy, anemia, and alterations in carbohydrate, lipid, and protein metabolism [6]