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So, yes, you can definitely overdo it with B12 injections

The reverse transsulfuration pathway affects the colonic microbiota and contributes to colitis in mice

10 Taken together, these observations indicate that immunogenic proteins and peptides can be present in the intestinal lumen and thus can serve as potential candidates for intestinal absorption and immune stimulation

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Keep the area clean and dry afterward

doi: 10.1016/S0140-6736(11)61452-9