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Mechanistically, it was shown that SLC7A11 interacts with arachidonate 12-lipoxygenase (ALOX12), and this interaction suppresses ALOX12s lipoxygenase activity to mediate polyunsaturated fatty acid (PUFA) peroxidation, thereby inhibiting ferroptosis

Autologous menstrual-blood MSCs have restored menses and increased oestradiol levels with minimal adverse events observed over a three-year follow-up period

The logistic complexity, high production failure rate (32%), and long duration to product availability (about 25 days) limit the clinical usefulness of this approach

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