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Further studies showed that NNMT can regulate Sirt1 expression and the stability of Sirt1 protein by lowering Sirt1 ubiquitination (4)

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By injecting melanoma cells into CD38/ mice, the function of CD38 could be studied and was found to be involved in (1) resistance to cell death, (2) tumor vascularization through a reduction in CD34, (3) recruitment of CAFs and (4) metastatic properties [50]