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In the presence of Mn 2+ , cGAS synthesizes cGAMP by a unique mechanism

doi: 10.1021/acsami.9b06162

In addition, the promotion of HDAC1 to SMAD7 ubiquitination [92, 93], thereby decreasing the half-life of the protein, is also observed, although the concrete mechanism remains unknown

In addition, knockdown of NNT increased cellular and mitochondrial NADH/total NAD(H) in human SK-Hep1 cells under basal and ADP-stimulated conditions compared with control shRNA-transfected cells, whereas cellular and mitochondrial NADPH/total NADP(H) was much lower in NNT-silenced cells, which correlated with an increase in mitochondrial ROS generation (33)

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[DOI] [PubMed] [Google Scholar] Marques RC, Drea JG, Manzatto AG Bastos WR, Bernardi JV, Malm O