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It confirmed ferroptosis as the core mechanism in PD pathogenesis synergistically induced by iron overload and inflammation, which activate ferroptosis by disrupting iron metabolism, inhibiting the antioxidant system and exacerbating lipid peroxidation, further causing dopaminergic neuronal damage, -syn aggregation, and PD-characteristic motor/cognitive impairments (186).Treating SH-SY5Y dopamine neurons with rotenone and using RhoNox-1 staining, followed by confocal microscopy observation and flow cytometry analysis, revealed significantly higher intracellular Fe 2+ in the rotenone group, confirming cellular iron overload (187)

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During the degradation stage, a cell retrieves amino acids and other precursor molecules from degraded proteins and removes damaged structures that may disturb its homeostasis

At 12 hpi, a single dose of 1 mg kg 1 Rif, alone or with 100 mg kg 1 KL1, was administered

Nordstrom, U