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DSIP is found in both free and protein-bound forms in the hypothalamus, limbic system, and pituitary gland, as well as in peripheral organs including the gut secretory cells, pancreas (where it co-localises with glucagon), and plasma with brain and plasma DSIP concentrations showing a marked diurnal variation that correlates with circadian rhythm in humans, with levels lowest in the morning and higher in the afternoon

A detailed introduction of the structure and function of BBB was given based on the mechanism of BBB, while comparing with the pathological changes of BBB in neurodegenerative diseases (NDDs), including activation of endothelial cells, the loose of tight junction and increase of BBB permeability

1 2 3 Grabbe 2004, pp

Nevertheless, the constraints of the cross-sectional study design and the lack of relevant data from literature prohibit any speculation on the potential reasons for these variations in observations