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Ambos tipos de compuestos pueden producir toxicidad significativa a nivel cutneo, siendo este efecto tan importante que hasta un 75% de los pacientes tratados con estas terapias las suspendan aunque el grado de toxicidad fuera i-ii5

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Some of these alterations can be passed by the parents of the individual, these types of cancer are known as hereditary cancers

The E3 ligase TRIM16 is a key suppressor of pathological cardiac hypertrophy

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