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In this species, inflammatory bowel disease (IBD), alimentary lymphoma, pancreatitis, cholangitis/cholangiohepatitis [29,30,35], and exocrine pancreatic insufficiency (EPI) [55] are the diseases frequently associated with cobalamin deficiency [29,30,35]
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NNMT-inhibitor research has shifted from early proof-of-concept work (20142017) to integrated preclinical programmes combining pharmacological NNMT inhibition with exercise-training research protocols (Dimet-Wiley 2024) and with hepatic/metabolic research endpoints (Zhang 2025)
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Results of curve fitting and threshold effect analysis After excluding participants with vitamin B12 1,000 pg/mL ( n = 15), a significant threshold effect was observed at 358.7 pg/mL
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