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We propose that ROS stress is the initial step in LOsG-inducing prediabetes

A decrease in the expression of the pro-ferroptotic proteins ACSL4, TFR1, and VDAC2/3 and a decrease in dihydroethidium (DHE) fluorescence, iron, malondialdehyde (MDA), and myeloperoxidase (MPO) were further observed in metformin-treated mice

Here the authors report a phase I clinical trial assessing the safety of clinically formulated TS in mesothelioma patients, and identify SLC7A11 as a potential mediator of TS resistance in pre-clinical models.