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Transgenic mice with elevated levels of n-3 PUFAs show reduced inflammatory responses and lipid peroxidation after injury, along with improved hypothalamic-pituitary-adrenal (HPA) axis function, suggesting that n-3 PUFAs play a protective role in alleviating metabolic imbalances associated with cachexia (75)

(PubMed) Luang-In V, Albaser AA, Nueno-Palop C, Bennett MH, Narbad A, Rossiter JT

[DOI] [PubMed] [Google Scholar] 163.Zhao L., Dong J., Hu Z., Li S., Su X., Zhang J., Yin Y., Xu T., Zhang Z., Chen H

Pivotal support for this strategy comes from the phase III KEYNOTE-522 trial in early-stage TNBC, in which neoadjuvant pembrolizumab combined with platinum-based chemotherapy significantly increased pathological complete response (pCR) rates and event-free survival compared with chemotherapy alone [55]

Induction of apoptosis by curcumin: Mediation by glutathione S-transferase P1-1 inhibition

The extract demonstrated negligible or only minimal negative effects on the inhibition ratios of these groups, which were primarily noted at high concentrations