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Antioxid Redox Signal 18(16):21062121

Gladyshev VN, Liu A, Novoselov SV, Krysan K, Sun QA, Kryukov VM, Kryukov GV, Lou MF: Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2

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Curcumin induces the expression of proteins such as SOCS1 and SOCS3, downregulates JAK2-STAT3/STAT6, inhibits the activity of the JAK-STAT signaling pathway, reduces the levels of pro-inflammatory cytokines, increases the levels of anti-inflammatory cytokines, and alleviates inflammation (Zhao et al., 2016)

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It also significantly impacts reducing the risk of endometrial, ovarian, and colon cancer (Schindler, 2010