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While the combination demonstrated favorable safety overall, unique toxicities emerged including allergic encephalitis (8%) and delayed emesis (16%), underscoring the need for neuroinflammatory monitoring in future trials [136]
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Thus, PUM2 is enriched in germline stem cells and embryonic stem cells [28], and murine PUM2 mutant testes are smaller than normal and contain some agametic seminiferous tubules [32]
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High-throughput isolation of Caenorhabditis elegans deletion mutants
& Schamel, W
