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The LC-MS/MS was performed on both polar and hydrophobic metabolites using an Ultimate 3000 RSLC nano coupled to an HPG pump or a Vanquish Flex UPLCs coupled to Orbitrap Fusion Lumos Tribrid mass spectrometer (Thermo Fisher Scientific) in HILIC LC-MS and RP-LC-MS, operated in positive and negative ionization modes as described previously 30

Verma D, Kantarjian H, Shan J, O'Brien S, Estrov Z, Garcia-Manero G, Koller C, Borthakur G , Cortes J

2019;144(5):1242-1253.e7

These anti-inflammatory and neurotrophic outcomes may play a significant role in the enhancement of mood and cognitive functioning (106)

In humans, pantothenic acid deficiency has been induced experimentally by co-administering a pantothenic acid antagonist and a pantothenic acid-deficient diet