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Ligand binding induces receptor dimerization and autophosphorylation of the intracellular tyrosine kinase domains, thereby activating key downstream signaling pathways such as PI3K-Akt and ERK1/2

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Examples include sulfur mustards (Davison et al., 1961), melphalan (Dulik et al., 1986), hexachlorobutadiene (Jones et al., 1985), bromobenzene (Monks et al., 1985), chloroform (Pohl et al., 1981), and bromotrichloromethane (Pohl et al., 1981)