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The following grades were used to determine the macroscopic score: 0 for non-visible changes,1 for mild erythema and mucosal edema or erosion, 2 for moderate edema, bleeding, or erosion, and 3 for severe edema, ulcers, or necrosis

That is why protocol-based peptide therapy consistently outperforms single-peptide therapy

doi: 10.1073/pnas.95.10.5818

Therefore, residues 294299 are considered important for substrate specificity

Permeability of injured and intact peripheral nerves and dorsal root ganglia

Subsequently, nuclear Nrf2 binds to small Maf proteins increasing the transcription of ARE-driven genes, which encode for phase II detoxification enzymes