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US Department of Health and Human Services, 2017

doi: 10.1016/S0140-6736(06)69705-5

Subcellular and cellular locations of nitric-oxide synthase isoforms as determinants of health and disease

58 A realistic hypothesis is that this specific enzyme could behave similarly also in other mammalian species
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Due to poor cell membrane permeability, poor targeting, poor stability, and low bioavailability, they have inevitable side effects [287]
