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When local teens Mike ( Grant Cramer ) and Debbie ( Suzanne Snyder ) also decide to investigate, they stumble into the Klowns spaceship and onto a bizarre plot to trap humans in cotton candy cocoons that dissolve flesh

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Importantly, ZSWIM8 binding appears incompatible with conformations observed for AGO2miRNA complexes not engaged with a TDMD trigger, as the PAZ and N domains would either clash with or fail to contact ZSWIM8 (refs
