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Central to this cascade is glutamate-induced hyperactivation of N -methyl- D -aspartate receptors (NMDA receptors), driving pathological calcium influx that overwhelms mitochondrial buffering capacity [103] (Fig

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Adjustments were made for individual traditional cardiac risk factors (age, gender, diabetes mellitus, systolic blood pressure, former or current cigarette smoking, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol), extent of CAD, left ventricular ejection fraction, history of MI, baseline medications (aspirin, statins, -blockers, and ACE inhibitors), and renal function by estimated creatinine clearance