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The first and perhaps most suspected trigger factor is the persistent and recurring virus infections such as EBV, Human Herpes Virus (HHV) and Parvovirus B19 [100]
a prominent theory suggests that low cellular iron modifies some aspects of the dopaminergic system either directly or indirectly
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These multidimensional factors spanning mitochondrial metabolism, cellular aging, metabolic function, and childhood trauma provided more detailed signatures to predict longitudinal changes in depression severity than each individual factor alone
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10.1001/jamapsychiatry.2017.0135 JAMA Psychiatry 6 BachmannR
