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Various factors, from genetic predisposition to body composition, type of drinks, length of time drinking and more, all influence how quickly ALDH can break down the toxic acetaldehyde

In cisplatin-induced chronic kidney disease models, miR-429-3p specifically inhibits key enzymes in the downstream BCAA catabolism pathway (e.g., ABAT, ALDH6A1) in renal proximal tubules, leading to abnormal intracellular BCAA accumulation [121]

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