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Description
It is frequently explored in research related to adipose tissue breakdown, reduced lipogenesis, metabolic regulation, and mechanisms affecting energy utilization without influencing IGF-1 activity

This phenomenon speeds up aging and the development of age-related diseases

PMID: 31121843
Implications and Recommendations for Future Studies As summarized in this review, NNMT plays important roles in obesity and T2D and is an attractive therapeutic target to prevent or treat obesity and associated T2D

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The term 'synergy' gets used when two compounds produce slightly better results together than alonebut true synergy means the combined effect exceeds the sum of individual effects, and that requires targeting rate-limiting steps in a shared pathway