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Contributing to erythrocyte metabolic reprogramming at high altitude, as well as under other hypoxic conditions, is an increase in plasma levels of adenosine
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Furthermore, we found that LA could elevate the level of GSH, which was consistent with the research that macrophage migration inhibitory factor (MIF) increased intracellular GSH content which protected against oxidative damage of tubular epithelial cell in vivo and in vitro (Unruh et al., 2019)
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Such cells essentially become addicted to MYC amplification
