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"Lowering homocysteine with B vitamins has no effect on biomarkers of bone turnover in older persons: a 2-y randomized controlled trial"

So if you are 100 lbs overweight you should lose between 70-80 lbs, for a 200 lbs overweight patient, the estimated weight loss is 140-160 lbs

Annales dEndocrinologie (2019) 80:848

Other Ingredients: Purified water, vegetable glycerin, natural flavor

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Research indicates that it can lead to a significant reduction in body weight, with some studies reporting up to a 10% reduction over a 12-week period